Targeting Therapeutic Stimulation Using Minimally Invasive Neuromodulation

Endovascular neural stimulation with platinum and platinum black modified electrodes

AR Harris, M Ruslim, H Xin, Z Shen, JY Liu, T Spencer, D Garrett, DB Grayden, SE John

2025-12-01

Recent work has shown the ability to record neural behaviour in pre-clinical studies from an endovascular location for over a year..

Ultra-flexible Coil for Wireless Endovascular Cortical Stimulation

YD Tai, J Villalobos, W Qi, H Xin, B Widdicombe, RR Unnithan, DB Grayden, SE John

2025-01-01

Endovascular devices hold promise for minimally invasive neural stimulation, particularly for applications in the treatment of neu..

Endovascular stimulation of the pudendal nerve using a stent-mounted electrode array

JY Liu, DB Grayden, JR Keast, SE John

2024-08-01

Objective. Previous preclinical and clinical studies have demonstrated that pudendal nerve is a promising target for restoring bla..

Feasibility of endovascular stimulation of the femoral nerve using a stent-mounted electrode array

JY Liu, DB Grayden, JR Keast, LC Booth, CN May, SE John

2024-06-01

Objective. Electrical stimulation of peripheral nerves has long been a treatment option to restore impaired neural functions that ..

Haemodynamics of stent-mounted neural interfaces in tapered and deformed blood vessels

Weijie Qi, Andrew Ooi, David B Grayden, Nicholas L Opie, Sam E John

2024-03-27

The endovascular neural interface provides an appealing minimally invasive alternative to invasive brain electrodes for recording ..

Computational modeling of endovascular peripheral nerve stimulation using a stent-mounted electrode array

JY Liu, DB Grayden, JR Keast, SE John

2023-06-01

Objective. Endovascular neuromodulation has attracted substantial interest in recent years as a minimally invasive approach to tre..

Electrochemistry in a Two- or Three-Electrode Configuration to Understand Monopolar or Bipolar Configurations of Platinum Bionic Implants

AR Harris, DB Grayden, SE John

2023-04-01

Electrodes are used in vivo for chemical sensing, electrophysiological recording, and stimulation of tissue. The electrode configu..

Computational Fluid Dynamics of Stent-Mounted Neural Interfaces in an Idealized Cerebral Venous Sinus

W Qi, A Ooi, DB Grayden, SE John

2023-01-01

Hemodynamic changes in stented blood vessels play a critical role in stent-associated complications. The majority of work on the h..

Wearable Transmitter Coil Design for Inductive Wireless Power Transfer to Implantable Devices

YD Tai, B Widdicombe, RR Unnithan, DB Grayden, SE John

2023-01-01

Wireless endovascular sensors and stimulators are emerging biomedical technologies for applications such as endovascular pressure ..

Vascular remodeling in sheep implanted with endovascular neural interface

SE John, S Donegan, TC Scordas, W Qi, P Sharma, K Liyanage, S Wilson, I Birchall, A Ooi, TJ Oxley, CN May, DB Grayden, NL Opie

2022-10-01

Objective. The aim of this work was to assess vascular remodeling after the placement of an endovascular neural interface (ENI) in..

The future potential of the Stentrode

Sam E John, David B Grayden, Takufumi Yanagisawa

2019-10-03

The StentrodeTM is a miniaturized neural interface that can record and stimulate the brain from within a blood vessel [1,2]. The S..

In Vivo Impedance Characterization of Cortical Recording Electrodes Shows Dependence on Electrode Location and Size

SE John, NV Apollo, NL Opie, GS Rind, SM Ronayne, CN May, TJ Oxley, DB Grayden

2019-03-01

Objective: Neural prostheses are improving the quality of life for those suffering from neurological impairments. Electrocorticogr..

Erratum to: Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable (Scientific Reports, (2018), 8, 1, (8427), 10.1038/s41598-018-26457-7)

SE John, NL Opie, YT Wong, GS Rind, SM Ronayne, G Gerboni, SH Bauquier, TJ O’Brien, CN May, DB Grayden, TJ Oxley

2018-12-01

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been..

Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI

PE Yoo, TJ Oxley, SE John, NL Opie, RJ Ordidge, TJ O’Brien, MA Hagan, YT Wong, BA Moffat

2018-12-01

Invasive Brain-Computer Interfaces (BCIs) require surgeries with high health-risks. The risk-to-benefit ratio of the procedure cou..

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

NL Opie, SE John, GS Rind, SM Ronayne, YT Wong, G Gerboni, PE Yoo, TJH Lovell, TCM Scordas, SL Wilson, A Dornom, T Vale, TJ O’Brien, DB Grayden, CN May, TJ Oxley

2018-12-01

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson’s disease, depression, epilepsy and ot..

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

SE John, NL Opie, YT Wong, GS Rind, SM Ronayne, G Gerboni, SH Bauquier, TJ O'Brien, CN May, DB Grayden, TJ Oxley

2018-12-01

Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. Howeve..

Cortical Brain Stimulation with Endovascular Electrodes

G Gerboni, SE John, SM Ronayne, GS Rind, CN May, TJ Oxley, DB Grayden, NL Opie, YT Wong

2018-10-26

Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for s..

Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated pipeline for skull stripping and co-registration of partial-coverage, ultra-high-field functional images

PE Yoo, JO Cleary, SC Kolbe, RJ Ordidge, TJ O’Brien, NL Opie, SE John, TJ Oxley, BA Moffat

2018-10-01

Objective: Ultra-high-field functional MRI (UHF-fMRI) allows for higher spatiotemporal resolution imaging. However, higher-resolut..

Visual evoked potentials determine chronic signal quality in a stent-electrode endovascular neural interface

G Gerboni, SE John, GS Rind, SM Ronayne, CN May, TJ Oxley, DB Grayden, NL Opie, YT Wong

2018-08-20

Brain-machine interfaces directly communicate between the brain and external devices. An effective trade-off between signal qualit..

Spatially dynamic recurrent information flow across long-range dorsal motor network encodes selective motor goals

PE Yoo, MA Hagan, SE John, NL Opie, RJ Ordidge, TJ O'Brien, TJ Oxley, BA Moffat, YT Wong

2018-06-01

Performing voluntary movements involves many regions of the brain, but it is unknown how they work together to plan and execute sp..

An ovine model of cerebral catheter venography for implantation of an endovascular neural interface

TJ Oxley, NL Opie, GS Rind, K Liyanage, SE John, S Ronayne, AJ McDonald, A Dornom, TJH Lovell, PJ Mitchell, I Bennett, S Bauquier, LN Warne, C Steward, DB Grayden, P Desmond, SM Davis, TJ O'Brien, CN May

2018-04-01

OBJECTIVE Neural interface technology may enable the development of novel therapies to treat neurological conditions, including mo..

Consistency of Long-Term Subdural Electrocorticography in Humans

ES Nurse, SE John, DR Freestone, TJ Oxley, H Ung, SF Berkovic, TJ O'Brien, MJ Cook, DB Grayden

2018-02-01

Objective: Subdural electrocorticography (ECoG) can provide a robust control signal for a brain-computer interface (BCI). However,..

7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution

PE Yoo, SE John, S Farquharson, JO Cleary, YT Wong, A Ng, CB Mulcahy, DB Grayden, RJ Ordidge, NL Opie, TJ O'Brien, TJ Oxley, BA Moffat

2018-01-01

Recent developments in accelerated imaging methods allow faster acquisition of high spatial resolution images. This could improve ..

Effect of Implant Duration, Anatomical Location and Electrode Orientation on Bandwidth Recorded with a Chronically Implanted Endovascular Stent-Electrode Array

N Opie, S John, G Rind, S Ronayne, Clive May, David Grayden, Thomas Oxley

2018-01-01

Access to the brain to implant recording electrodes has conventionally required a craniotomy. To mitigate risks of open brain surg..

The ovine motor cortex: A review of functional mapping and cytoarchitecture

SE John, TJH Lovell, NL Opie, S Wilson, TC Scordas, YT Wong, GS Rind, S Ronayne, SH Bauquier, CN May, DB Grayden, TJ O'Brien, TJ Oxley

2017-09-01

In recent years, sheep (Ovis aries) have emerged as a useful animal model for neurological research due to their relatively large ..

Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel

NL Opie, NR Van Der Nagel, SE John, K Vessey, GS Rind, SM Ronayne, EL Fletcher, CN May, TJ Obrien, TJ Oxley

2017-04-01

Objective: Recently, we reported the development of a stent-mounted electrode array (Stentrode) capable of chronically recording n..

A Minimally Invasive Endovascular Stent-Electrode Array for Chronic Recordings of Cortical Neural Activity

Thomas J Oxley, Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Anthony N Burkitt, David B Grayden, Clive N May, Terence J O'Brien

2017-01-01

Intracranial electrode arrays for recording and stimulating electrical brain activity have facilitated major advances in the treat..

Feasibility of a chronic, minimally invasive endovascular neural interface

NL Opie, GS Rind, SE John, SM Ronayne, DB Grayden, AN Burkitt, CN May, TJ O'Brien, TJ Oxley

2016-10-13

Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability o..

Suitability of nitinol electrodes in neural prostheses such as endovascular neural interfaces

YT Wong, NL Opie, SE John, G Gerboni, GS Rind, SM Ronayne, KE Fox, TJ Oxley, DB Grayden

2016-10-13

A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel..

Chronic impedance spectroscopy of an endovascular stent-electrode array

NL Opie, SE John, GS Rind, SM Ronayne, DB Grayden, AN Burkitt, CN May, TJ O'Brien, TJ Oxley

2016-07-05

Objective. Recently, we reported a minimally invasive stent-electrode array capable of recording neural signals from within a bloo..

The evolution of endovascular electroencephalography: Historical perspective and future applications

RK Sefcik, NL Opie, SE John, CP Kellner, J Mocco, TJ Oxley

2016-01-01

Current standard practice requires an invasive approach to the recording of electroencephalography (EEG) for epilepsy surgery, dee..